Simple research comparison
GLP-1 peptides: Semaglutide vs Tirzepatide vs Retatrutide (GLP-3)
GLP-1 research peptides are among the most studied classes in metabolic research. Below we simply compare three well-known peptides by how many receptors they engage and the areas they are studied in. None of this is a claim or a promise of results.
Research Use Only
This page organises research information. It does not contain use instructions or a promise of results.
The key difference
One, two or three receptors.
The key difference is the number of receptors: Semaglutide engages one (GLP-1), Tirzepatide two (GLP-1 and GIP) and Retatrutide three (GLP-1, GIP and glucagon) — which is why it is often called "GLP-3". The more receptors, the more complex the compound's research profile.
RUO limitation
Strictly for laboratory research use. Not intended for human consumption, diagnosis, treatment or prevention of disease.