Research Use Only (RUO). For laboratory research only. Not for human or veterinary use.
Muscle & Performance
Strength: 2000 IU
For research use only. hCG (chorionic gonadotropin) is a glycoprotein hormone made of two protein chains, the α and β subunits. It is studied for its action at the LH/hCG receptor.
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This product is intended exclusively for laboratory research use. It is not intended for human consumption, diagnosis, treatment, or prevention of disease.
Documentation on request
There is no published document for this specific SKU variant at the moment.
Contact us about documentationResearch overview
For research use only. hCG (chorionic gonadotropin) is a glycoprotein hormone made of two protein chains, the α and β subunits. It is studied for its action at the LH/hCG receptor. Reference details: Muscle & Performance / SKU AV-HCG-2000IU.
Batch documentation and COA, where available, are linked to the specific product batch and SKU.
This product is intended exclusively for laboratory research use. It is not intended for human consumption, diagnosis, treatment, or prevention of disease.
Product profile
92
amino acids in the alpha subunit — shared with LH, FSH and TSH
145
amino acids in the beta subunit — where the specificity sits
≈36 kDa
molecular weight of the heterodimer — roughly a third of it is carbohydrate
Research context
hCG is a hormone the placenta naturally produces in pregnancy.
In pharmacology it is used because it mimics, almost perfectly, another of the body's hormones — the one that gives the testes their orders.
A glycoprotein hormone. It acts as a functional mimic of luteinizing hormone (LH) at its receptor.
It sends the same signal as the hormone LH, but it lasts longer.
The signal reaches specific cells in the testes and tells them to produce testosterone.
It is this local testosterone that triggers the process of sperm production.
It activates the LH/hCG receptor on Leydig cells, driving steroidogenesis and, indirectly, spermatogenesis.
The strongest evidence is in male infertility where the problem starts in the brain, not the testes.
In a contemporary case series, gonadotropin therapy achieved spermatogenesis in about three out of four men.
74%
spermatogenesis induction
68%
pregnancy achieved
35
men in the series
hCG stimulation studies confirm that, even under stress, the cells of the testes keep their capacity to respond.
In the same series, monotherapy was compared with hCG combined with FSH.
33%
hCG alone
78%
hCG + FSH
The combination was clearly more effective at inducing spermatogenesis than hCG alone.
hCG is a prescription medicine. Its use is under medical supervision and after assessment of the hormonal profile.
It is also a prohibited doping substance: it is on the WADA list and is banned specifically in men.
Who may benefit depends on the underlying cause — which is why the literature stresses the importance of stratification before anything else.
Huijben et al., gonadotropins in hypogonadotropic hypogonadism, Reprod Fertil 2026. Esteves et al., hCG in non-obstructive azoospermia, Andrology 2025.
Used in a controlled laboratory setting as a reference standard in hCG immunoassays and antibody-specificity work, for in vitro binding and activation studies at the LHCGR, for signalling pathway analysis (cAMP generation, beta-arrestin recruitment) in cell lines, for comparative work against recombinant LH, for glycosylation-pattern characterization, and for identity and purity confirmation by HPLC and mass spectrometry.
Research Use Only. For laboratory research exclusively. Not intended for human or veterinary use, diagnosis, treatment, or disease prevention. Chorionic gonadotropin is a prescription medicine and appears on the World Anti-Doping Agency (WADA) Prohibited List; its use in a sporting context constitutes an anti-doping rule violation. No dosages, protocols or administration guidance are provided, and nothing on this page constitutes medical advice. The literature cited concerns basic research and approved pharmaceutical products and does not transfer to research-grade material.
Comparison
| Feature | HCG (this product) | Kisspeptin-10 |
|---|---|---|
| Position on the axis | Downstream — acts directly on the gonads | Upstream — acts on the hypothalamus |
| Receptor | LHCGR (LH/choriogonadotropin receptor) | KISS1R / GPR54 |
| Molecule type | Two-subunit glycoprotein hormone | Linear single-chain peptide |
| Size | 92 + 145 amino acids, ≈36 kDa | 10 amino acids, the C-terminal fragment of kisspeptin-54 |
| Glycosylation | Extensive — roughly a third of the mass | None |
| Origin | Human placental hormone (or recombinant) | Synthetic fragment of a native peptide |
| Regulatory status | Prescription medicine; WADA-prohibited substance | Research molecule with no medicinal approval |
| Product form | Lyophilized powder | Lyophilized powder |
References
Product information
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